According to a research report “Plasma Fractionation Market is set to exhibit a notable CAGR of 6.7% Projected to reach USD 36.7 billion by 2027during the forecast period, up from its USD 26.5 billion value in 2022. The market’s robust growth can be attributed to several key driving factors, including the rising application of immunoglobulins in treating various therapeutic areas such as hematology, neurology, and pulmonology. Additionally, the use of protease inhibitors to address lung diseases and hepatic diseases with a growing incidence rate further contributes to the market expansion.

Despite the promising growth prospects, the market faces certain challenges that could temper its progress. The increased cost of plasma products may create a barrier for some patients, and limited reimbursements could hinder accessibility for others. Moreover, the emergence and adoption of recombinant alternatives present a competitive challenge to plasma fractionation products.

the global plasma fractionation market is on a trajectory of growth, driven by the escalating application of immunoglobulins and protease inhibitors in various therapeutic treatments. However, challenges related to cost, reimbursement limitations, and the rise of recombinant alternatives demand careful consideration as stakeholders plan their strategies for the future.

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The report also mentions that clinical research organizations, hospitals, and clinics are the key end-users of plasma fractionation products. These institutions require plasma-derived products for various research studies, clinical trials, and patient treatments.

Key Market Player:

The global plasma fractionation market is highly consolidated. The prominent players operating in this market include CSL (Australia), Grifols, S.A. (Spain), Shire (US), Octapharma AG (Switzerland), Kedrion S.P.A (Italy), LFB (France), Biotest AG (Germany), Sanquin (Netherlands), China Biologic Products Holdings Inc. (China), GC Pharma (Korea), Bio Products Ltd. (UK), Japan Blood Products Organization (Japan), Emergent BioSolutions (US), Shanghai Raas Blood Products Co., Ltd. (China), Intas Pharmaceuticals Ltd. (India), Bharat Serum Vaccines Limited (India), SK Plasma (Korea), Sichuan Yuanda Shuyang Pharmaceutical Co., Ltd. (China), KabaFusion (US), Centurion Pharma (Istanbul), ADMA Biologics, Inc. (US), PlasmaGen BioSciences Pvt. Ltd. (India), Virchow Biotech Private Limited (India), Fusion Healthcare (India), and Hemarus Therapeutics Limited (India). Geographic expansions and collaborations are the key growth strategies undertaken by these companies to maintain their positions in the market.

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In 2021, the IVIG (intravenous immunoglobulin) segment accounted for the largest share of the Immunoglobulins market within the plasma fractionation industry. This segment’s significant market share can be attributed to its widespread use in various disease indications, both on-label and off-label. IVIG is utilized for conditions such as dermatomyositis, Guillain-Barré syndrome, chronic inflammatory demyelinating polyneuropathy (CIDP), immune cytopenias, hypogammaglobulinemia, primary antibody deficiency, vacuities, multiple sclerosis, asthma, systemic lupus erythematosus, and other ailments. The shorter response period of IVIG compared to steroids or oral immunosuppressants, increasing healthcare investments, and the growing number of patients with autoimmune diseases and other pathological conditions are key factors contributing to the growth of this market segment.

On the other hand, the pulmonology segment is expected to exhibit the highest compound annual growth rate (CAGR) during the forecast period. This segment focuses on applications related to lung diseases and respiratory disorders. The significant growth in the pulmonology segment is primarily driven by the increased use of protease inhibitors, particularly alpha-1-antitrypsin, in recent years. As the global geriatric population continues to rise, the prevalence of conditions like alpha-1-antitrypsin deficiency (AATD) and chronic obstructive pulmonary disease (COPD) is also expected to increase. This, in turn, is anticipated to drive the demand for plasma-derived alpha-1-antitrypsin in the coming years, making the pulmonology segment the fastest-growing during the forecast period.

North America was the largest regional market for plasma fractionation market in 2021

The global plasma fractionation market is segmented into North America, Europe, Asia Pacific, Latin America, and the Middle East and Africa. In 2021, North America accounted for the largest share of the plasma fractionation market, followed by Europe and the Asia Pacific. The large share of North America in the global market is attributed to the innovations in manufacturing processes such as presence of advanced virus removal technologies (such as nanofiltration), and the development of newer plasma products such as ceruloplasmin and IgA, high number of registered hemophilic patients and largest number of plasma collection center. However, the market in the Asia Pacific is expected to grow at the highest CAGR during the forecast period. This can be attributed to the growth in increasing number of hemophilic patients, as well as factors such as the increasing number of organ transplantations, modified regulations and monitoring of the implementation of procedures, policies, and guidelines to promote innovation and commercialization, increasing awareness about technologically advanced products in the region, and the improving standard of living across several APAC countries.

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Recent Development:

• Baxter International Inc. acquired ChemoSera S.A. in 2022. The acquisition will expand Baxter’s portfolio of plasma fractionation products and enable the company to expand its presence in the European markets.
• Biovian Oy acquired ViroClinics Biosciences B.V. in 2022. The acquisition will expand Biovian’s plasma fractionation capabilities, increase its global presence, and enable the company to enhance its offerings in the field of plasma-derived biopharmaceuticals.
• Takeda Pharmaceutical Company Limited acquired Shire Plc in 2022. This acquisition will broaden Takeda’s product portfolio, enabling the company to expand its presence in the plasma fractionation market.
• Grifols S.A. acquired Hologic Inc. in 2022. The acquisition of Hologic’s business will enable Grifols to expand its offering of plasma fractionation products and services, as well as its global presence.
• CSL Limited acquired Terumo BCT in 2023. This acquisition will enable CSL to expand its product portfolio and strengthen its position in the global plasma fractionation market.

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