The Global report “Cell Culture Market in terms of revenue was estimated to be worth $27.9 billion in 2023 and is poised to reach $51.3 billion by 2028, growing at a CAGR of 12.9% from 2023 to 2028. The new research study consists of an industry trend analysis of the market. The new research study consists of industry trends, pricing analysis, patent analysis, conference and webinar materials, key stakeholders, and buying behaviour in the market. The growth of this market is majorly driven by government support and funding for cell-based research and emerging cell culture technologies for cell-based vaccines. Further, the demand for 3D over 2D cell cultures is creating opportunities the growth of this market.

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The global cell culture market is expected to grow at a CAGR of 12.9% during the forecast period. The growth of this market is majorly driven by the increasing government support and funding for cell-based research, adoption of single-use technologies, emerging cell culture technologies for cell-based vaccines and incidence of infectious diseases. On the other hand, the expensive cell biology research is restraining the growth of this market.

DRIVER: Adoption of single-use technologies

Over the last few years, biopharmaceutical manufacturers have increasingly adopted single-use technologies (SUTs). These SUTs have helped comply with stringent regulations and control costs through multiple benefits. Some single-use bioreactors (SUBs) have low operating volume requirements; this allows for more flexibility in production volumes scaled up over time, depending on the demand. Also, SUTs reduce cross-contamination risk, facilitating rapid changeovers and multiple production batches. SUTs also require less space than multiple-use bioreactors, less capital investment, and less sterilization for storage. This reduces the overall operating and maintenance costs and the environmental impact of these operations. The advantages of SUTs have fueled their adoption in the biopharmaceutical sector, thus driving the growth of the overall market during the forecast period.

RESTRAINT: Limitations in producing high-density cell cultures

Although the adoption of advanced technologies such as microcarriers is increasing in high-density cell cultures, there are several limitations associated with their use, which makes the process of cell culture very laborious and expensive. Some of them are: Agitation is required in a stirred-tank bioreactor to make a homogenous cell culture system. Fluid turbulence damages cells and results in cell debris formation and low cell yield, thus increasing downstream processing costs. The number of microcarriers needs to be increased for higher culture density. This, however, leads to a higher degree of collisions (bead-to-bead or microcarrier-bound-cells to mechanical impeller), resulting in cell death and decreased cell yield.

OPPORTUNITY: Growth hotspots in emerging economies

Developing countries such as China, India, and other countries in the Asia Pacific are expected to offer significant growth opportunities for players operating in the market. The booming biopharmaceutical sector in these countries, increased risk of pandemics (such as swine flu and COVID-19), less-stringent regulatory guidelines, and the low manufacturing cost advantage are the major factors attracting market players to set up and expand their presence in these countries.

The equipment segment accounted for the second largest share, by product in the the cell culture market in 2022.

Based on equipment, the cell culture market is segmented into supporting equipment, bioreactors, and storage equipment. Cell culture involves the extensive use of laboratory equipment such as bioreactors, storage equipment, and cell culture-supporting equipment. The growing awareness about the benefits of cell culture-based vaccines (coupled with the growing regulatory approval for these products), increasing production of mAbs, and the introduction of technologically advanced products for high-demand applications (such as cell & gene therapy and regenerative medicine) are the key factors driving the growth of the cell culture equipment market.

The monoclonal antibody production segment accounted for the largest share of the biopharmaceutical production segment in the cell culture market in 2022.

Based on biopharmaceutical production, the cell culture market is categorized into monoclonal antibody production, vaccine production, and other therapeutic protein production. Monoclonal antibodies are multifunctional components of the immune system that fight infections. Most antibodies generated as a natural response are polyclonal, which means they are produced by several B lymphocytes. Monoclonal antibodies, on the contrary, are produced in laboratories and can bind to single specific targets in the body, such as antigens on the surface of certain cancer cells.

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The North America region catered the largest share of the cell culture market in 2022.

The growing regulatory approvals for and awareness of cell culture-based vaccines, rising investments in biopharmaceutical R&D coupled with various initiatives from the leading companies, and conferences and symposia that create awareness of the latest cell culture trends are the key factors driving the growth of the cell culture market in North America. Biopharmaceutical companies in North America focus on R&D activities to develop and commercialize novel drugs and therapies. Additionally, various initiatives from leading companies have accelerated growth in North America.

Key players in the cell culture market include Thermo Fisher Scientific, Inc. (US), Merck KGaA (Germany), Danaher Corporation (US), and Sartorius AG (Germany), Corning Incorporated (US).

Recent Developments:

• In October 2021, Thermo Fisher Scientific Inc. (US) launched the Gibco Cell Therapy Systems (CTS) NK-Xpander Medium, which supports the large-scale growth and culture of functional natural killer (NK) cells with or without the use of feeder cells.
• In September 2021, Cytiva expanded its manufacturing capacity for bioprocessing single-use consumables by launching 3 new manufacturing facilities in under ten months.

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