The Global Cryo-Electron Microscopy Market in terms of revenue was estimated to be worth $1.1 billion in 2022 and is poised to reach $2.1 billion by 2028, growing at a CAGR of 11.6% from 2022 to 2028. The increasing focus on nanotechnology has risen the use of cryo-electron microscopes globally. Different academic and research institutes has increased the adoption of technologically advanced cryo-electron microscopes.

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Cryo-electron Microscopy Market Dynamics

Drivers: Technological advancements in cryo-electron microscopes

Recent years have seen significant advancements in cryo-electron microscopes, such as developments in direct electron detectors (DEDs) and data analysis software such as cryoSPARC, SerialEM, and CryoDiscovery. These technologically advanced detectors have improved sensors and detect electrons at increased frame rates with higher detector quantum efficiency (DQE). Recent advancements have also eliminated the challenges associated with sample preparation. These advancements has increased the popularity of the instruments in different sectors such as pharmaceutical & biotech industries and research institutes.

Restraints: High equipment costs

Recent technological advancements, newly added features, and high resolution have increased the popularity of cryo-electron microscopes. There is a consistent rise in the cost of these systems with the addition of sample preparation & transfer systems and customized software for analyzing the generated images. The basic software solution is priced low but the software with advanced features and specific applications is often costly. In addition, there are recurrent expenses in the form of maintenance costs, which ultimately drive up the overall cost of ownership. This high cost has left users reliant on government and private research funding, which restricts market growth to a certain extent.

Opportunities: Growing opportunities in emerging markets

Developing countries, including China, India, Russia, and Brazil, offer significant growth opportunities for players in the microscopy market. Government funding for R&D in advanced microscopes has increased considerably in these countries. In addition to government funding, original equipment manufacturers (OEMs) in emerging markets provide opportunities for key players to outsource their microscopy products as a cost-saving strategy. Increasing use of cryo-electron microscopy technique for structural analysis of proteins and other biomolecules at an atomic scale for various applications in life science research is driving the growth of the market.

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Challenges: Shortage of skilled professionals

Skilled personnel are required to use advanced cryo-electron microscopes. High-end microscopes are required to be maintained properly. This requires qualified service engineers to ensure optimal performance. The individual operating the high end microscopes requires to have a interdisciplinary knowledge to study the characterization of biological molecules at a nanoscale. The complexity of cryo-electron microscopes makes the shortage of skilled professionals a key challenge to their use and adoption.

Key Market Players:

As of 2021, prominent players in the cryo-electron microscopy market are Thermo Fisher Scientific (US), Danaher (US), JEOL Ltd. (Japan), Intertek Group Plc (UK), and Charles River Laboratories (US). 

Recent Developments

• In 2022, Thermo Fisher Scientific (US) launched the Glacios 2 Cryo-Transmission Electron Microscope (Cryo-TEM). The product features high-resolution capabilities and helps in drug discovery research.
• In 2022, Leica Microsystems (US), a subsidiary of Danaher launched a new Coral Cryo-electron workflow solution to support researchers with high-precision confocal 3D targeting
• In 2021, JEOL Ltd. (Japan) launched CRYO ARM 300 II. It is a cold emission cryo-electron microscope. It aims to enable the observation of biological specimens under high resolution

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